Greene County, being a part of land grant by King Charles II of England in 1663, was first settled around 1710 by immigrants from Maryland, Virginia, and parts of North Carolina. Upon arrival of these new settlers, great numbers of settlers were killed, driven off, or tortured by the Tuscarora Indians. However, on March 20-23, 1713, a fighting force of South Carolinians and Yemassce Indians, under Colonel Murice Moore, defeated the Tuscarora, under the leadership of Chief Hancock. With the "demise" of the Indian threat, County settlers advanced in their various economic pursuits.
In 1758, the area now recognized as Greene and Lenoir Counties was separated from Johnston and named Dobbs for the Royal Governor. This section was bisected to form Glasgow County in honor of the Secretary of State. However, Glasgow and accomplices were involved in issuing fraudulent land grants and were duly indicted. The residents of the county then changed its name to Greene, in honor of Nathaniel Greene, one of General Washington's right-hand men.
The county seat, Snow Hill, is the largest town and major commercial center in the county. The town draws its name from the historic white sandy banks of nearby Contentnea Creek. Among the towns and communities in the county are Hookerton, Maury, and Walstonburg. These old established communities are relatively self-enduring and traditionally stable.